{
    "protocol": "The synthesis of hydrophilic polymers with functional groups can be achieved through various methods including physical cross-linking, dynamic cross-linking, and chemical cross-linking. These methods allow for the engineering of the gelation process to meet specific needs. Advanced chemical approaches can be utilized to manipulate the shape, structure, and architecture of hydrogels, enabling the incorporation of desirable functionalities such as adjustable properties, excellent biocompatibility, controllable degradability, and mechanical compatibility with biological tissues."
}